Natrilix SR Use In Pregnancy & Lactation

Pregnancy: There is no data or only limited data (fewer than 300 pregnancy outcomes) on the use of indapamide in pregnant women. Prolonged exposure to thiazide diuretics during the third trimester of pregnancy can reduce maternal plasma volume as well as uteroplacental blood flow, which may cause feto-placental ischaemia and growth retardation.
Animal studies do not indicate direct or indirect harmful effects on reproduction.
As a precautionary measure, it is preferable to avoid the use of indapamide during pregnancy.
Breast-feeding: There is insufficient information on the excretion of indapamide/metabolites in human milk. Hypersensitivity to sulphonamide-derived medicines and hypokalaemia might occur. A risk to the newborns/infants cannot be excluded.
Indapamide is structurally very close to thiazide diuretics which have been associated, during breast-feeding, with a decrease or even suppression of lactation.
Indapamide is not recommended while breast-feeding.
Fertility: Reproductive toxicity studies showed no effect on fertility in female and male rats. No effects on human fertility are anticipated.